Two Dobzhansky-Muller Genes Interact to Cause Hybrid Lethality in Drosophila

Science. 2006 Nov 24;314(5803):1292-5. doi: 10.1126/science.1133953.

Abstract

The Dobzhansky-Muller model proposes that hybrid incompatibilities are caused by the interaction between genes that have functionally diverged in the respective hybridizing species. Here, we show that Lethal hybrid rescue (Lhr) has functionally diverged in Drosophila simulans and interacts with Hybrid male rescue (Hmr), which has functionally diverged in D. melanogaster, to cause lethality in F1 hybrid males. LHR localizes to heterochromatic regions of the genome and has diverged extensively in sequence between these species in a manner consistent with positive selection. Rapidly evolving heterochromatic DNA sequences may be driving the evolution of this incompatibility gene.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromosomal Proteins, Non-Histone / metabolism
  • Chromosome Mapping
  • Crosses, Genetic
  • Drosophila / genetics*
  • Drosophila / physiology
  • Drosophila Proteins / chemistry
  • Drosophila Proteins / genetics*
  • Drosophila Proteins / metabolism
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • Evolution, Molecular*
  • Female
  • Genes, Insect*
  • Genetic Speciation
  • Hybridization, Genetic*
  • Male
  • Molecular Sequence Data
  • Selection, Genetic
  • Transformation, Genetic
  • Transgenes

Substances

  • Chromosomal Proteins, Non-Histone
  • Drosophila Proteins
  • Hmr protein, Drosophila
  • Lhr protein, Drosophila
  • heterochromatin protein 1, Drosophila

Associated data

  • GENBANK/BK005905
  • GENBANK/BK005906
  • GENBANK/BK005907
  • GENBANK/BK005908
  • GENBANK/BK005909
  • GENBANK/BK005910
  • GENBANK/BK005911
  • GENBANK/BK005912
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  • GENBANK/EF057388
  • GENBANK/EF057389