SNAREing immunity: the role of SNAREs in the immune system

Nat Rev Immunol. 2006 Dec;6(12):919-29. doi: 10.1038/nri1980.


The trafficking of molecules and membranes within cells is a prerequisite for all aspects of cellular immune functions, including the delivery and recycling of cell-surface proteins, secretion of immune mediators, ingestion of pathogens and activation of lymphocytes. SNARE (soluble-N-ethylmaleimide-sensitive-factor accessory-protein receptor)-family members mediate membrane fusion during all steps of trafficking, and function in almost all aspects of innate and adaptive immune responses. Here, we provide an overview of the roles of SNAREs in immune cells, offering insight into one level at which precision and tight regulation are instilled on immune responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytokines / metabolism
  • Humans
  • Immune System / cytology
  • Inflammation Mediators / metabolism
  • Macrophages / immunology*
  • Membrane Fusion*
  • Phagocytosis
  • SNARE Proteins / genetics
  • SNARE Proteins / physiology*


  • Cytokines
  • Inflammation Mediators
  • SNARE Proteins