Progress and obstacles in the development of an AIDS vaccine

Nat Rev Immunol. 2006 Dec;6(12):930-9. doi: 10.1038/nri1959.


Recent experimental observations suggest approaches to immunization that might finally result in at least a partially effective vaccine against infection with HIV-1. In particular, advances in our understanding of the contribution of vaccine-elicited cellular immunity to protecting memory CD4(+) T cells from virus-mediated destruction provide rational strategies for the development of this vaccine. This is therefore an ideal time to review our current understanding of HIV-1 and its control by the immune system, as well as the remaining problems that must be solved to facilitate the development of an effective vaccine against AIDS.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • AIDS Vaccines / immunology*
  • Animals
  • Antibodies, Viral
  • Disease Models, Animal
  • HIV Infections / immunology*
  • HIV Infections / prevention & control*
  • HIV Infections / transmission
  • HIV-1 / immunology*
  • Humans
  • Mucous Membrane / immunology*
  • Primates


  • AIDS Vaccines
  • Antibodies, Viral