CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x

Proc Natl Acad Sci U S A. 1991 Jul 15;88(14):6224-8. doi: 10.1073/pnas.88.14.6224.


The leukocyte receptor CD62, which is expressed on activated platelets and endothelial cells, is shown to mediate cell adhesion by binding a sialylated carbohydrate structure, sialyl-Lewis x, found on neutrophils, monocytes, and tumor cells. This structure has previously been identified as the ligand for another member of the LEC-CAM family of cell adhesion molecules, endothelial cell-leukocyte adhesion molecule 1, which also binds neutrophils and monocytes. The results demonstrate that although the two LEC-CAMs differ in their biological activities by their distribution and mode of expression, they are capable of mediating cell adhesion by recognition of the same carbohydrate ligand.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antigens, CD / immunology
  • Blood Platelets / immunology
  • Blood Platelets / physiology*
  • Carbohydrate Conformation
  • Carbohydrate Sequence
  • Cell Adhesion Molecules / immunology*
  • Cell Adhesion*
  • Cell Line
  • Cells, Cultured
  • E-Selectin
  • Endothelium, Vascular / immunology
  • Endothelium, Vascular / physiology*
  • Humans
  • Lewis X Antigen / immunology*
  • Ligands
  • Liposomes
  • Molecular Sequence Data
  • Neutrophils / immunology
  • Neutrophils / physiology*
  • P-Selectin
  • Platelet Activation
  • Platelet Membrane Glycoproteins / immunology*
  • Receptors, Immunologic / immunology


  • Antibodies, Monoclonal
  • Antigens, CD
  • Cell Adhesion Molecules
  • E-Selectin
  • Lewis X Antigen
  • Ligands
  • Liposomes
  • P-Selectin
  • Platelet Membrane Glycoproteins
  • Receptors, Immunologic