Mechanism of modulation of GABA-activated current by internal calcium in rat central neurons

Brain Res. 1991 Apr 19;546(2):355-7. doi: 10.1016/0006-8993(91)91502-r.


GABA-activated currents in Purkinje cells isolated from rat cerebellum were investigated. Increase of intracellular Ca2+ in the physiological range of concentrations caused a decrease in GABA-activated chloride currents. This effect resulted from a decrease of both the maximal values of GABA-activated currents and possibly from the affinity of GABAA receptors. Therefore, the mechanism of Ca2+ effect on GABAA receptors in central rat neurons differs from that in bullfrog sensory neurons.

MeSH terms

  • Animals
  • Calcium / physiology*
  • Cerebellum / cytology
  • Chlorine / metabolism
  • In Vitro Techniques
  • Ion Channels / physiology*
  • Kinetics
  • Purkinje Cells / physiology*
  • Rats
  • gamma-Aminobutyric Acid / physiology*


  • Ion Channels
  • Chlorine
  • gamma-Aminobutyric Acid
  • Calcium