Staufen, a Gene Required to Localize Maternal RNAs in the Drosophila Egg

Cell. 1991 Jul 12;66(1):51-63. doi: 10.1016/0092-8674(91)90138-o.

Abstract

The posterior group gene staufen is required both for the localization of maternal determinants to the posterior pole of the Drosophila egg and for bicoid RNA to localize correctly to the anterior pole. We report the cloning and sequencing of staufen and show that staufen protein is one of the first molecules to localize to the posterior pole of the oocyte, perhaps in association with oskar RNA. Once localized, staufen is found in the polar granules and is required to hold other polar granule components at the posterior pole. By the time the egg is laid, staufen protein is also concentrated at the anterior pole, in the same region as bicoid RNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Cloning, Molecular
  • Drosophila / genetics*
  • Drosophila / physiology
  • Drosophila Proteins*
  • Female
  • Gene Expression
  • Genes*
  • Insect Hormones / genetics*
  • Molecular Sequence Data
  • Mutation
  • Oogenesis*
  • Ovum / physiology*
  • RNA / genetics*
  • RNA-Binding Proteins*
  • Restriction Mapping

Substances

  • Drosophila Proteins
  • Insect Hormones
  • RNA-Binding Proteins
  • stau protein, Drosophila
  • RNA

Associated data

  • GENBANK/M60962
  • GENBANK/M64383
  • GENBANK/M64384
  • GENBANK/M64707
  • GENBANK/M69111
  • GENBANK/S44812
  • GENBANK/S44816
  • GENBANK/S44821
  • GENBANK/S56137
  • GENBANK/S56139