Mitochondrial toxins and neurodegenerative diseases

Front Biosci. 2007 Jan 1;12:986-1007. doi: 10.2741/2119.

Abstract

The selective loss of a particular subset of neurons is a common feature of neurodegenerative disorders. A failure in respiratory chain complex activities in mitochondria seems to be a causative factor. The aim of this review is to describe the most important toxins affecting the mitochondrial function, which could be involved in the incidence of some of these diseases: MPTP, rotenone and 3-nitropropionic (3-NPA).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Humans
  • Huntington Disease / chemically induced
  • MPTP Poisoning / chemically induced*
  • Mitochondria / drug effects*
  • Neurodegenerative Diseases / chemically induced*
  • Nitro Compounds / toxicity*
  • Parkinson Disease, Secondary / chemically induced
  • Propionates / toxicity*
  • Rotenone / toxicity*
  • Succinate Dehydrogenase / antagonists & inhibitors
  • Tetrahydroisoquinolines / chemistry
  • Tetrahydroisoquinolines / metabolism

Substances

  • Nitro Compounds
  • Propionates
  • Tetrahydroisoquinolines
  • Rotenone
  • Succinate Dehydrogenase
  • 3-nitropropionic acid