Can pure fruit and vegetable juices protect against cancer and cardiovascular disease too? A review of the evidence

Int J Food Sci Nutr. 2006 May-Jun;57(3-4):249-72. doi: 10.1080/09637480600858134.


While it is widely accepted that fruit and vegetables (F&V) lower the risk of cancer, and cardiovascular disease (CVD), the role of pure fruit and vegetable (PFV) juices is often downplayed. This review poses two questions: Are the protective benefits of F&V dependent upon constituents lacking in PFV juices (e.g. fibre)? Do PFV juices impact on disease risk when considered separately from F&V? Studies comparing the effects of fibre and antioxidants were reviewed, yielding the finding that the impact of F&V may relate more strongly to antioxidants, than to fibre. For the second question, high-quality published studies that considered PFV juices were reviewed. The impact of PFV juices on cancer risk was weakly positive, although a lack of human data and contradictory findings hampered conclusions. For CVD, there was convincing evidence from epidemiological and clinical studies that PFV juices reduced risk via a number of probable mechanisms. It was concluded that the view that PFV juices are nutritionally inferior to F&V, in relation to chronic disease risk reduction, is unjustified.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antioxidants / administration & dosage
  • Beverages*
  • Cardiovascular Diseases / prevention & control*
  • Dietary Fiber / administration & dosage
  • Fruit*
  • Humans
  • Neoplasms / prevention & control*
  • Risk Assessment
  • Vegetables*


  • Antioxidants
  • Dietary Fiber