Halichondria sulfonic acid, a new HIV-1 inhibitory guanidino-sulfonic acid, and halistanol sulfate isolated from the marine sponge Halichondria rugosa Ridley & Dendy

Nat Prod Res. 2006 Oct;20(12):1129-35. doi: 10.1080/14786410600879748.

Abstract

A new sulfur-containing guanidino derivative, halichondria sulfonic acid (1) showing anti-HIV-1 activity, and halistanol trisulfate (2) with anti-tumor activity have been isolated from the marine sponge Halichondria rugosa Ridley & Dendy collected in the Chinese Southern Sea. The structure of 1 was elucidated by analysis of spectroscopic and crystal data.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-HIV Agents / chemistry*
  • Anti-HIV Agents / isolation & purification
  • Anti-HIV Agents / toxicity
  • Cell Line
  • Cell Survival / drug effects
  • China
  • Crystallography, X-Ray
  • Enzyme-Linked Immunosorbent Assay
  • Guanidines / chemistry*
  • Guanidines / isolation & purification
  • Guanidines / toxicity
  • HIV-1 / drug effects*
  • Inhibitory Concentration 50
  • Molecular Structure
  • Oceans and Seas
  • Porifera / chemistry*
  • Spectrophotometry, Infrared
  • Spectrum Analysis
  • Sterols / chemistry*
  • Sterols / isolation & purification
  • Sterols / toxicity
  • Sulfonic Acids / chemistry*
  • Sulfonic Acids / isolation & purification
  • Sulfonic Acids / toxicity
  • Tetrazolium Salts
  • Thiazoles

Substances

  • Anti-HIV Agents
  • Guanidines
  • Halichondria sulfonic acid
  • Sterols
  • Sulfonic Acids
  • Tetrazolium Salts
  • Thiazoles
  • halistanol trisulfate
  • thiazolyl blue