Re-evaluating cell-cycle regulation by E2Fs

Cell. 2006 Dec 1;127(5):871-4. doi: 10.1016/j.cell.2006.11.019.


Activation of E2F transcription factors is thought to drive the expression of genes essential for the transition of cells from G1 to S phase and for the initiation of DNA replication. However, this textbook view of E2Fs is increasingly under challenge. Here we discuss an alternative model for how E2Fs may work.

MeSH terms

  • Animals
  • Cell Cycle*
  • E2F Transcription Factors / chemistry
  • E2F Transcription Factors / metabolism*
  • Models, Genetic
  • Protein Structure, Tertiary
  • Repressor Proteins / metabolism
  • Transcriptional Activation


  • E2F Transcription Factors
  • Repressor Proteins