Proteins kinases: chromatin-associated enzymes?

Cell. 2006 Dec 1;127(5):887-90. doi: 10.1016/j.cell.2006.11.015.


Protein kinases contribute to the regulation of gene expression by interacting with transcription factors that are recruited to the regulatory regions of genes. Previous studies investigated the role of protein kinases in transcription initiation. Here, we discuss new insights gleaned from recent work showing that kinases can also interact with chromatin throughout the entire transcribed region of target genes (Pokholok et al., 2006; Proft et al., 2006).

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromatin / metabolism*
  • Protein Kinases / metabolism*
  • Substrate Specificity
  • Transcription, Genetic
  • Transcriptional Elongation Factors / metabolism


  • Chromatin
  • Transcriptional Elongation Factors
  • Protein Kinases