A strain of Salmonella enterica serovar Virchow isolated in Turkey and carrying a CTX-M-3 extended-spectrum beta-lactamase

J Chemother. 2006 Jun;18(3):307-10. doi: 10.1179/joc.2006.18.3.307.


A multiply resistant strain of Salmonella enterica subsp. enterica serovar Virchow was isolated in November 2002 from a catheterized patient admitted to the SSK Training Hospital in Ankara, Turkey. This isolate showed an antimicrobial susceptibility pattern compatible with the presence of a CTX-M-type ESBL, namely resistance to cefotaxime, aztreonam and cefepime, and intermediate susceptibility to ceftazidime. On checking for the presence of the bla(TEM), bla(SHV), and bla(CTX-M )resistance genes by PCR, negative results were obtained with the primers specific for SHV and TEM genes, while positive results were obtained with those specific for CTX-M-type genes. After sequencing, the beta-lactamase was identified as CTX-M-3. This is the first report of this enzyme in Salmonella Virchow and represents a further disquieting threat to the therapy of infections caused by Salmonella isolates.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Drug Resistance, Multiple, Bacterial*
  • Hospitals, Teaching
  • Humans
  • Polymerase Chain Reaction
  • Salmonella enterica / drug effects
  • Salmonella enterica / genetics*
  • Salmonella enterica / isolation & purification
  • Turkey
  • Urinary Catheterization
  • beta-Lactamases / genetics*


  • Anti-Bacterial Agents
  • beta-lactamase CTX-M-3
  • beta-Lactamases