TEDDY--The Environmental Determinants of Diabetes in the Young: an observational clinical trial

Ann N Y Acad Sci. 2006 Oct;1079:320-6. doi: 10.1196/annals.1375.049.

Abstract

The aim of the TEDDY study is to identify infectious agents, dietary factors, or other environmental agents, including psychosocial factors, which may either trigger islet autoimmunity, type 1 diabetes mellitus (T1DM), or both. The study has two end points: (a) appearance of islet autoantibodies and (b) clinical diagnosis of T1DM. Six clinical centers screen newborns for high-risk HLA genotypes. As of December 2005 a total of 54,470 newborns have been screened. High-risk HLA genotypes among 53,560 general population (GP) infants were 2576 (4.8%) and among 910 newborns with a first-degree relative (FDR) were 194 (21%). A total of 1061 children have been enrolled. The initial enrollment results demonstrate the feasibility of this complex and demanding a prospective study.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Alleles
  • Autoantibodies / immunology
  • Child
  • Child, Preschool
  • Cohort Studies
  • Diabetes Mellitus, Type 1 / diagnosis
  • Diabetes Mellitus, Type 1 / genetics*
  • Environmental Exposure*
  • Feasibility Studies
  • Follow-Up Studies
  • Genetic Testing
  • HLA Antigens / genetics
  • Haplotypes
  • Humans
  • Infant
  • Infant, Newborn
  • Islets of Langerhans / immunology
  • Risk Factors
  • Time Factors

Substances

  • Autoantibodies
  • HLA Antigens