Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions

W-P Fong; C H K Cheng; W-K Tang

doi:10.1007/s00018-006-6089-4

Antiquitin, a relatively unexplored member in the superfamily of aldehyde dehydrogenases with diversified physiological functions

Cell Mol Life Sci. 2006 Dec;63(24):2881-5. doi: 10.1007/s00018-006-6089-4.

Authors

W-P Fong¹, C H K Cheng, W-K Tang

Affiliation

¹ Department of Biochemistry, The Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China. wpfong@cuhk.edu.hk

PMID: 17131062
DOI: 10.1007/s00018-006-6089-4

Abstract

Antiquitin is a member of the aldehyde dehydrogenase superfamily. Sequence analyses indicate that the protein is highly conserved from plants to animals. The plant antiquitins are generally believed to play a role in osmoregulation and/or detoxification. The physiological functions of animal antiquitins remain largely elusive, their involvement in a number of human diseases has been implicated.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Aldehyde Dehydrogenase / physiology*
Animals
Humans
L-Aminoadipate-Semialdehyde Dehydrogenase
Molecular Sequence Data
Plant Proteins / physiology*
Proteins / physiology
Water-Electrolyte Balance*

Substances

Plant Proteins
Proteins
ALDH7A1 protein, human
Aldehyde Dehydrogenase
Aldh7a1 protein, rat
L-Aminoadipate-Semialdehyde Dehydrogenase