Effects of intended weight loss on morbidity and mortality: possible explanations of controversial results

Nutr Rev. 2006 Nov;64(11):502-7. doi: 10.1111/j.1753-4887.2006.tb00183.x.


Long-term, population-based, observational studies have shown that intended weight loss does not always reduce the mortality associated with obesity. The effects of weight loss on mortality may be a balance between the effects of the loss of harmful abdominal and ectopic fat mass and the loss of beneficial peripheral subcutaneous fat mass and lean body mass.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipose Tissue / metabolism
  • Body Composition / physiology*
  • Humans
  • Muscle, Skeletal / metabolism
  • Obesity / epidemiology*
  • Obesity / mortality*
  • Weight Loss* / physiology