Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 58 (4), 798-836

International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

Affiliations
Review

International Union of Pharmacology. LXVI. Orphan Nuclear Receptors

Gérard Benoit et al. Pharmacol Rev.

Abstract

Half of the members of the nuclear receptors superfamily are so-called "orphan" receptors because the identity of their ligand, if any, is unknown. Because of their important biological roles, the study of orphan receptors has attracted much attention recently and has resulted in rapid advances that have helped in the discovery of novel signaling pathways. In this review we present the main features of orphan receptors, discuss the structure of their ligand-binding domains and their biological functions. The paradoxical existence of a pharmacology of orphan receptors, a rapidly growing and innovative field, is highlighted.

Similar articles

See all similar articles

Cited by 66 PubMed Central articles

See all "Cited by" articles

LinkOut - more resources

Feedback