Abstract
The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 microg/mL. [structure: see text]
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Basidiomycota / metabolism*
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacology
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Lactones / chemistry*
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Lactones / pharmacology
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Lipase / antagonists & inhibitors*
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Magnetic Resonance Spectroscopy
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Molecular Conformation
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Spectrometry, Mass, Electrospray Ionization
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Spectrophotometry, Infrared
Substances
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Enzyme Inhibitors
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Lactones
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vibralactone
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Lipase