Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans

Org Lett. 2006 Dec 7;8(25):5749-52. doi: 10.1021/ol062307u.

Abstract

The structure and absolute configuration of vibralactone (1) from the cultures of the Basidiomycete Boreostereum vibrans were established by spectroscopic methods and computational methods. Vibralactone, an unusual fused beta-lactone-type metabolite, was found to inhibit pancreatic lipase with an IC50 of 0.4 microg/mL. [structure: see text]

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Basidiomycota / metabolism*
  • Enzyme Inhibitors / chemistry*
  • Enzyme Inhibitors / pharmacology
  • Lactones / chemistry*
  • Lactones / pharmacology
  • Lipase / antagonists & inhibitors*
  • Magnetic Resonance Spectroscopy
  • Molecular Conformation
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared

Substances

  • Enzyme Inhibitors
  • Lactones
  • vibralactone
  • Lipase