DOMINO: a database of domain-peptide interactions

Nucleic Acids Res. 2007 Jan;35(Database issue):D557-60. doi: 10.1093/nar/gkl961. Epub 2006 Nov 29.


Many protein interactions are mediated by small protein modules binding to short linear peptides. DOMINO ( is an open-access database comprising more than 3900 annotated experiments describing interactions mediated by protein-interaction domains. DOMINO can be searched with a versatile search tool and the interaction networks can be visualized with a convenient graphic display applet that explicitly identifies the domains/sites involved in the interactions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Databases, Protein*
  • Internet
  • Ligands
  • Peptides / chemistry*
  • Peptides / metabolism
  • Protein Interaction Mapping
  • Protein Structure, Tertiary*
  • User-Computer Interface


  • Ligands
  • Peptides