A new antifungal macrolide, eushearilide, isolated from Eupenicillium shearii

J Antibiot (Tokyo). 2006 Sep;59(9):597-600. doi: 10.1038/ja.2006.80.

Abstract

In screening for antifungal substances, a new macrolide, eushearilide (1), was isolated from Eupenicillium shearii IFM54447. The structure of 1 was established to be 24-membered macrolide having a non-conjugated diene and a choline phosphate ester moetiy on the basis of detailed investigation of NMR, UV, IR and MS spectral data. Compound 1 showed antifungal activity against various fungi and yeasts, including human pathogens Aspergillus fumigatus, Trichophyton spp. and Candida spp.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / chemistry
  • Antifungal Agents / isolation & purification*
  • Antifungal Agents / pharmacology*
  • Aspergillus fumigatus / drug effects
  • Candida / drug effects
  • Eurotiales / metabolism*
  • Macrolides / chemistry
  • Macrolides / isolation & purification*
  • Macrolides / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / chemistry
  • Phosphorylcholine / isolation & purification
  • Phosphorylcholine / pharmacology
  • Spectrum Analysis
  • Trichophyton / drug effects

Substances

  • Antifungal Agents
  • Macrolides
  • eushearilide
  • Phosphorylcholine