Approaches and recommendations for estimating minimally important differences for health-related quality of life measures

COPD. 2005 Mar;2(1):63-7. doi: 10.1081/copd-200050663.


We describe currently available approaches for estimating the minimally important difference (MID) and their associated strengths and weaknesses. Specifically, we show that anchor-based methods should be the primary method of estimating the MID because of the limitations of distribution-based methods. In addition, we provide recommendations for estimating the MID in future research.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Data Interpretation, Statistical
  • Guidelines as Topic
  • Humans
  • Pulmonary Disease, Chronic Obstructive / therapy*
  • Quality of Life*
  • Treatment Outcome