Synthesis of loliolide, actinidiolide, dihydroactinidiolide, and aeginetolide via cerium enolate chemistry

J Org Chem. 2006 Dec 8;71(25):9513-6. doi: 10.1021/jo0611566.

Abstract

Loliolide, aeginetolide, actinidiolide, and dihydroactinidiolide were synthesized in racemic form from a single common intermediate, prepared through the 1,2 addition of the cerium enolate of ethyl acetate to 2,6,6-trimethylcylohexenone.

MeSH terms

  • Carotenoids / chemical synthesis*
  • Carotenoids / chemistry
  • Cerium / chemistry*
  • Magnetic Resonance Spectroscopy

Substances

  • Cerium
  • Carotenoids