Avian influenza is a World Organization for Animal Heath-listed disease that has become of great importance both for animal and human health. The increased relevance of avian influenza in the fields of animal and human health has highlighted the lack of scientific information on several aspects of the disease, which has hampered the adequate management of some of the recent crises. Millions of animals have died and there is growing concern over the loss of human lives and over the management of the pandemic potential. This special report will review the control methods for avian influenza infections in poultry that are currently available. The application of control policies, ranging from stamping out to emergency and prophylactic vaccination, are discussed on the basis of data generated from recent outbreaks, in the light of new regulations and also in view of the maintenance of animal welfare. Poultry veterinarians working for the industry or for the public sector represent the first line of defense against the pandemic threat and for the prevention and control of this infection in poultry and in wild birds.