Recent acquisitions in acquired and congenital von Willebrand disorders

Clin Chim Acta. 2007 Feb;377(1-2):62-9. doi: 10.1016/j.cca.2006.10.017. Epub 2006 Nov 10.


von Willebrand factor is a multimeric plasma protein that mediates platelet adhesion as well as platelet aggregation at sites of vascular injury and, moreover, acts as a carrier of factor VIII. Its deficiency is associated with a bleeding tendency. The progresses in the pathophysiology, diagnosis and management of inherited von Willebrand disease and acquired von Willebrand syndrome will be discussed in this review.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Humans
  • von Willebrand Diseases / classification
  • von Willebrand Diseases / metabolism*
  • von Willebrand Diseases / pathology*
  • von Willebrand Diseases / therapy
  • von Willebrand Factor / genetics
  • von Willebrand Factor / metabolism


  • Biomarkers
  • von Willebrand Factor