Abstract
Phylogenetic analysis of SARS coronavirus isolates based on the spike gene and protein sequence using Neighbor-Joining, maximum likelihood and Bayesian inference methods indicated that a recent human SARS-CoV isolate was closer to some human SARS-CoV isolates from earlier epidemic phase than to the SARS-CoV-like viruses isolated from wild animals during previous epidemic phase. A reasonable judgment based on phylogenetic relationship and sequence variations it is likely that the recent human SARS-CoV isolate is closer to an unknown SARS-CoV predecessor.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Animals
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Coronaviridae Infections / virology*
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Genetic Variation*
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Humans
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Membrane Glycoproteins / chemistry
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Membrane Glycoproteins / genetics
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Phylogeny
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Sequence Analysis
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Severe acute respiratory syndrome-related coronavirus / classification
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Severe acute respiratory syndrome-related coronavirus / genetics*
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins / chemistry
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Viral Envelope Proteins / genetics
Substances
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Membrane Glycoproteins
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Spike Glycoprotein, Coronavirus
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Viral Envelope Proteins
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spike glycoprotein, SARS-CoV