Mammalian collagen receptors

Matrix Biol. 2007 Apr;26(3):146-55. doi: 10.1016/j.matbio.2006.10.007. Epub 2006 Nov 10.

Abstract

Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of tissues, but are also intimately involved in controlling cell behaviour. The hallmark of collagens is a triple helix made up of polypeptide chains containing glycine-X-Y repeats. A structurally and functionally diverse group of cell surface receptors mediates the recognition of triple-helical collagen: integrins, discoidin domain receptors, glycoprotein VI, leukocyte-associated IG-like receptor-1, and members of the mannose receptor family. In this review, we discuss the structure and function of these receptors, focussing on the principles involved in collagen recognition.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Collagen / chemistry
  • Collagen / genetics
  • Collagen / metabolism
  • Discoidin Domain Receptors
  • Integrins / chemistry
  • Integrins / genetics
  • Integrins / metabolism
  • Lectins, C-Type / chemistry
  • Lectins, C-Type / genetics
  • Lectins, C-Type / metabolism
  • Mannose-Binding Lectins / chemistry
  • Mannose-Binding Lectins / genetics
  • Mannose-Binding Lectins / metabolism
  • Models, Molecular
  • Platelet Membrane Glycoproteins / chemistry
  • Platelet Membrane Glycoproteins / genetics
  • Platelet Membrane Glycoproteins / metabolism
  • Protein Conformation
  • Receptor Protein-Tyrosine Kinases / chemistry
  • Receptor Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases / metabolism
  • Receptors, Cell Surface / chemistry
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / metabolism
  • Receptors, Collagen* / chemistry
  • Receptors, Collagen* / genetics
  • Receptors, Collagen* / metabolism
  • Receptors, Immunologic / chemistry
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism
  • Receptors, Mitogen / chemistry
  • Receptors, Mitogen / genetics
  • Receptors, Mitogen / metabolism

Substances

  • Integrins
  • Lectins, C-Type
  • Mannose-Binding Lectins
  • Platelet Membrane Glycoproteins
  • Receptors, Cell Surface
  • Receptors, Collagen
  • Receptors, Immunologic
  • Receptors, Mitogen
  • leukocyte-associated immunoglobulin-like receptor 1
  • mannose receptor
  • platelet membrane glycoprotein VI
  • Collagen
  • Discoidin Domain Receptors
  • Receptor Protein-Tyrosine Kinases