Serotonin's SOS signal

Cell Metab. 2006 Dec;4(6):415-7. doi: 10.1016/j.cmet.2006.11.010.

Abstract

Neurotransmitters relay signals within the brain and to peripheral tissues, allowing communication between nerve cells. New work from in this issue of Cell Metabolism reveals that, in C. elegans, serotonin functions during conditions of stress through the well-characterized insulin/IGF-1 signaling pathway, suggesting a mechanism for the stress response.

Publication types

  • Comment

MeSH terms

  • Active Transport, Cell Nucleus / genetics
  • Animals
  • Animals, Genetically Modified
  • Caenorhabditis elegans / genetics
  • Caenorhabditis elegans / metabolism*
  • Caenorhabditis elegans Proteins / genetics
  • Caenorhabditis elegans Proteins / metabolism*
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism
  • Fluoxetine / pharmacology
  • Forkhead Transcription Factors / genetics
  • Forkhead Transcription Factors / metabolism
  • Models, Animal
  • Mutation
  • Neurons / metabolism*
  • Neurosecretory Systems / metabolism
  • Receptor, IGF Type 1 / genetics
  • Receptor, IGF Type 1 / immunology
  • Receptor, Insulin / genetics
  • Receptor, Insulin / metabolism
  • Selective Serotonin Reuptake Inhibitors / pharmacology
  • Serotonin / genetics
  • Serotonin / metabolism*
  • Signal Transduction* / drug effects
  • Transcription Factors / genetics
  • Transcription Factors / metabolism*

Substances

  • Caenorhabditis elegans Proteins
  • Forkhead Transcription Factors
  • Serotonin Uptake Inhibitors
  • Transcription Factors
  • daf-16 protein, C elegans
  • Fluoxetine
  • Serotonin
  • DAF-2 protein, C elegans
  • Receptor, IGF Type 1
  • Receptor, Insulin