Fat uses a TOLL-road to connect inflammation and diabetes

Cell Metab. 2006 Dec;4(6):417-9. doi: 10.1016/j.cmet.2006.11.008.


The link between inflammation and diabetes is well established, but the nature of the link is unresolved. Obesity, inflammation, and insulin resistance are major characteristics of diabetes. A study by Flier and colleagues () identifies Toll-like receptor 4 signaling activated by fatty acids as part of that link. This receptor mediates inflammatory events and insulin resistance in peripheral organs.

Publication types

  • Review

MeSH terms

  • Animals
  • Diabetes Mellitus / immunology*
  • Fatty Acids / immunology*
  • Humans
  • Inflammation / immunology
  • Insulin Resistance / immunology*
  • Obesity / immunology*
  • Toll-Like Receptor 4 / immunology*


  • Fatty Acids
  • TLR4 protein, human
  • Toll-Like Receptor 4