Sugihiratake mushroom (angel's wing mushroom)-induced cryptogenic encephalopathy may involve vitamin D analogues

Biol Pharm Bull. 2006 Dec;29(12):2514-8. doi: 10.1248/bpb.29.2514.


In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10 g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.

MeSH terms

  • Agaricales*
  • Brain Diseases / etiology*
  • Foodborne Diseases*
  • Humans
  • Mass Spectrometry
  • Vitamin D / analogs & derivatives*


  • Vitamin D