doi: 10.1038/nmeth985.
Epub 2006 Dec 3.
Tomographic molecular imaging and 3D quantification within adult mouse organs
Affiliations
- PMID: 17143281
- DOI: 10.1038/nmeth985
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Tomographic molecular imaging and 3D quantification within adult mouse organs
Nat Methods.
2007 Jan.
Abstract
A convenient technology to quantify three-dimensional (3D) morphological features would have widespread applications in biomedical research. Based on combined improvements in sample preparation, tomographic imaging and computational processing, we present a procedure for high-resolution 3D quantification of structures within intact adult mouse organs. Using the nonobese diabetic (NOD) mouse model, we demonstrate a correlation between total islet beta-cell volume and the onset of type-1 diabetes.
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