Diversity of LEF/TCF action in development and disease

Oncogene. 2006 Dec 4;25(57):7492-504. doi: 10.1038/sj.onc.1210056.


Lymphoid enhancer factor/T cell factor proteins (LEF/TCFs) mediate Wnt signals in the nucleus by recruiting beta-catenin and its co-activators to Wnt response elements (WREs) of target genes. This activity is important during development but its misregulation plays a role in disease such as cancer, where overactive Wnt signaling drives LEF/TCFs to transform cells. The size of the LEF/TCF family is small: approximately four members in vertebrates and one orthologous form in flies, worms and hydra. However, size belies complexity. The LEF/TCF family exhibits extensive patterns of alternative splicing, alternative promoter usage and activities of repression, as well as activation. Recent work from numerous laboratories has highlighted how this complexity has important biological consequences in development and disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Cell Nucleus / metabolism
  • DNA / chemistry
  • Gene Expression Regulation*
  • Humans
  • Lymphoid Enhancer-Binding Factor 1 / metabolism
  • Lymphoid Enhancer-Binding Factor 1 / physiology*
  • Models, Genetic
  • Protein Structure, Tertiary
  • Signal Transduction
  • TCF Transcription Factors / metabolism
  • TCF Transcription Factors / physiology*
  • Transcription, Genetic


  • Lymphoid Enhancer-Binding Factor 1
  • TCF Transcription Factors
  • DNA