Wnt signaling and gastrointestinal tumorigenesis in mouse models

Oncogene. 2006 Dec 4;25(57):7522-30. doi: 10.1038/sj.onc.1210058.


The canonical Wnt signaling plays important roles in embryonic development and tumorigenesis. For the latter, induced mutations in mice have greatly contributed to our understanding of the molecular mechanisms of cancer initiation and progression. Here, I will review recent reports on gastrointestinal cancer model mice, with an emphasis on the roles of the Wnt signal pathway. They include: mouse models for familial adenomatous polyposis; modifying factors that affect mouse intestinal polyposis, including the genes that help cancer progression; Wnt target genes that affect mouse intestinal polyposis; and a mouse model of gastric cancer that mimics Helicobacter pyroli infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenomatous Polyposis Coli / genetics
  • Animals
  • Disease Models, Animal
  • Disease Progression
  • Gastrointestinal Neoplasms / genetics
  • Gastrointestinal Neoplasms / metabolism*
  • Humans
  • Mice
  • Mice, Transgenic
  • Models, Biological
  • Mutation
  • Signal Transduction
  • Wnt Proteins / genetics
  • Wnt Proteins / physiology*


  • Wnt Proteins