Pharmacokinetics-pharmacodynamics of antimicrobial therapy: it's not just for mice anymore

Clin Infect Dis. 2007 Jan 1;44(1):79-86. doi: 10.1086/510079. Epub 2006 Nov 27.


Since the advent of the modern era of antimicrobial chemotherapy in the 1930s, animal infection models have allowed for the in vivo evaluation of antimicrobial agents for the treatment of experimentally induced infection. Today, animal pharmacokinetic-pharmacodynamic (PK-PD) infection models serve as a cornerstone of the preclinical assessment process for antibacterial agents and dose and dosing interval selection, as decision support for setting in vitro susceptibility breakpoints, and, finally, for the evaluation of the meaning of in vitro resistance. Over the past 15 years, considerable PK-PD data have been derived from infected patients for many classes of antimicrobial agents. These data provide the opportunity to confirm knowledge gained from animal PK-PD infection models.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use*
  • Area Under Curve
  • Bacteremia / drug therapy
  • Bacteremia / microbiology
  • Bacterial Infections / drug therapy*
  • Bacterial Infections / microbiology
  • Community-Acquired Infections / drug therapy*
  • Community-Acquired Infections / microbiology
  • Disease Models, Animal*
  • Humans
  • Mice
  • Respiratory Tract Infections / drug therapy
  • Respiratory Tract Infections / microbiology
  • Skin Diseases, Bacterial / drug therapy
  • Skin Diseases, Bacterial / microbiology


  • Anti-Bacterial Agents