Effect of polysaccharides from Ganoderma lucidum on streptozotocin-induced diabetic nephropathy in mice

J Asian Nat Prod Res. 2006 Dec;8(8):705-11. doi: 10.1080/10286020500289071.


The effects of Ganoderma lucidum polysaccharides (GL-PS) on renal complication in streptozotocin-induced diabetic mice have been investigated in the present study. C57BL/6J mice were made diabetic by injection of streptozotocin and GL-PS (125 and 250 mg kg-1) was administered for 8 weeks. Body weight was monitored every week. Serum glucose, creatinine (Cr), blood urea nitrogen (BUN), triglyceride (TG) and urinary albumin excretion (UAE) were measured after 8 weeks of treatment. Glomerular size and mesangial matrix index were assayed by morphometric analysis. Renal expression of transforming growth factor-beta1 (TGF-beta1) were determined by immunochemistry. Renal malondialdehyde (MDA) level and superoxide dismutase (SOD) activities were also evaluated. GL-PS was able to reduce the serum Cr and BUN levels and UAE compared with diabetic model mice in a dose-dependent manner. Increasing serum glucose and triglyceride levels in diabetic mice could also be lowered by GL-PS. Moreover, GL-PS had the capacity to improve the renal morphometric changes and oxidative stress state of diabetic mice. In summary, GL-PS can improve the metabolic abnormalities of diabetic mice and prevent or delay the progression of diabetic renal complications.

Publication types

  • Comparative Study

MeSH terms

  • Albuminuria / metabolism
  • Analysis of Variance
  • Animals
  • Blood Glucose
  • Blood Urea Nitrogen
  • Creatinine / blood
  • Diabetic Nephropathies / chemically induced*
  • Diabetic Nephropathies / drug therapy*
  • Immunohistochemistry
  • Kidney Glomerulus / metabolism
  • Kidney Glomerulus / pathology
  • Malondialdehyde / metabolism
  • Mice
  • Mice, Inbred C57BL
  • Polysaccharides / pharmacology
  • Polysaccharides / therapeutic use*
  • Reishi / chemistry*
  • Streptozocin / toxicity*
  • Superoxide Dismutase / metabolism
  • Transforming Growth Factor beta / metabolism
  • Triglycerides / blood


  • Blood Glucose
  • Polysaccharides
  • Transforming Growth Factor beta
  • Triglycerides
  • Malondialdehyde
  • Streptozocin
  • Creatinine
  • Superoxide Dismutase