E-cadherin repression contributes to c-Myc-induced epithelial cell transformation

Oncogene. 2007 May 24;26(24):3582-6. doi: 10.1038/sj.onc.1210132. Epub 2006 Dec 4.

Abstract

c-Myc oncoprotein is overexpressed in a significant proportion of human epithelial cancers, and experimental overexpression of c-Myc in epithelial cells promotes tumour formation. However, it is not known how c-Myc promotes epithelial cell tumour formation. We report that c-Myc expression in human mammary epithelial cells induces a dramatic change in cell morphology, with some characteristics of an 'epithelial to mesenchymal transition'. E-cadherin expression is repressed by a post-transcriptional mechanism in cells expressing c-Myc. Furthermore, E-cadherin repression is necessary for c-Myc-induced cell transformation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Breast Neoplasms / genetics
  • Breast Neoplasms / pathology
  • Cadherins / genetics
  • Cadherins / metabolism*
  • Cell Transformation, Neoplastic*
  • Cells, Cultured
  • Epithelial Cells / pathology*
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Mammary Glands, Human / pathology
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism*

Substances

  • Cadherins
  • MYC protein, human
  • Proto-Oncogene Proteins c-myc