Meta-analysis of serotonin transporter gene promoter polymorphism (5-HTTLPR) association with selective serotonin reuptake inhibitor efficacy in depressed patients

Mol Psychiatry. 2007 Mar;12(3):247-57. doi: 10.1038/ Epub 2006 Dec 5.


The serotonin transporter gene promoter polymorphism (5-HTTLPR) has been repeatedly associated with antidepressant response in mood disorder patients, but findings are not consistent across studies. A meta-analysis was performed on 15 studies including data of 1435 subjects. We tested three phenotypes: remission rate, response rate and response rate within 4 weeks using the cochrane review manager. We observed a significant association of the s/s variant of 5-HTTLPR with remission rate (P<0.0001) and both s/s and s/l variants with response rate (P=0.0002). Response rate within 4 weeks was associated in both models (P=0.003-P<0.00001). This effect is quite robust to ethnic differences although a significant heterogeneity is present in Asian samples.

Publication types

  • Comparative Study
  • Meta-Analysis

MeSH terms

  • Adult
  • Aged
  • Depressive Disorder / drug therapy*
  • Depressive Disorder / genetics*
  • Female
  • Humans
  • MEDLINE / statistics & numerical data
  • Male
  • Middle Aged
  • Polymorphism, Genetic*
  • Promoter Regions, Genetic*
  • Serotonin Plasma Membrane Transport Proteins / genetics*
  • Serotonin Uptake Inhibitors / therapeutic use*


  • Serotonin Plasma Membrane Transport Proteins
  • Serotonin Uptake Inhibitors