Dietary anthocyanin-rich tart cherry extract inhibits intestinal tumorigenesis in APC(Min) mice fed suboptimal levels of sulindac

J Agric Food Chem. 2006 Dec 13;54(25):9322-8. doi: 10.1021/jf0612169.

Abstract

A promising approach for cancer chemoprevention might be a combination therapy utilizing dietary phytochemicals and anticarcinogenic pharmaceuticals at a suboptimal dosage to minimize any potential adverse side effects. To test this hypothesis, various dosages of anthocyanin-rich tart cherry extract were fed in combination with suboptimal levels of the nonsteroidal anti-inflammatory drug sulindac to APCMin mice for 19 weeks. By the end of the feeding period, fewer mice that were fed the anthocyanin-rich extract in combination with sulindac lost more than 10% of body weight than mice fed sulindac alone. Mice that were fed anthocyanin-rich extract (at any dose) in combination with sulindac had fewer tumors and a smaller total tumor burden (total tumor area per mouse) in the small intestine when compared to mice fed sulindac alone. These results suggest that a dietary combination of tart cherry anthocyanins and sulindac is more protective against colon cancer than sulindac alone.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenomatous Polyposis Coli / genetics
  • Animals
  • Anthocyanins / administration & dosage*
  • Anthocyanins / analysis
  • Antineoplastic Agents / administration & dosage*
  • Diet
  • Female
  • Fruit / chemistry*
  • Intestinal Neoplasms / genetics
  • Intestinal Neoplasms / prevention & control*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Mutant Strains
  • Mutation
  • Plant Extracts / administration & dosage
  • Plant Extracts / chemistry
  • Prunus / chemistry*
  • Sulindac / administration & dosage*

Substances

  • Anthocyanins
  • Antineoplastic Agents
  • Plant Extracts
  • Sulindac