Chemotherapy of brain tumour using doxorubicin bound to surfactant-coated poly(butyl cyanoacrylate) nanoparticles: revisiting the role of surfactants

J Control Release. 2007 Jan 22;117(1):51-8. doi: 10.1016/j.jconrel.2006.10.015. Epub 2006 Oct 21.


Poly(butyl cyanoacrylate) nanoparticles coated with poloxamer 188 (Pluronic) F68) and also, as shown previously, polysorbate 80 (Tween 80) considerably enhance the anti-tumour effect of doxorubicin against an intracranial glioblastoma in rats. The investigation of plasma protein adsorption on the surface of the drug-loaded nanoparticles by two-dimensional electrophoresis (2-D PAGE) revealed that both surfactants, besides other plasma components, induced a considerable adsorption of apolipoprotein A-I (ApoA-I). It is hypothesized that delivery of doxorubicin to the brain by means of nanoparticles may be augmented by the interaction of apolipoprotein A-I that is anchored on the surface of the nanoparticles with the scavenger receptor class B type I (SR-BI) located at the blood-brain barrier. This is the first study that shows a correlation between the adsorption of apolipoprotein A-I on the nanoparticle surface and the delivery of the drug across the blood-brain barrier.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Animals
  • Antibiotics, Antineoplastic / administration & dosage*
  • Antibiotics, Antineoplastic / therapeutic use*
  • Apolipoprotein A-I / metabolism
  • Blood Proteins / chemistry
  • Blood-Brain Barrier
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Chemical Phenomena
  • Chemistry, Physical
  • Cyanoacrylates*
  • Dextrans
  • Doxorubicin / administration & dosage*
  • Doxorubicin / therapeutic use*
  • Electrophoresis, Polyacrylamide Gel
  • Glioblastoma / drug therapy*
  • Glioblastoma / pathology
  • Nanoparticles*
  • Particle Size
  • Poloxamer
  • Rats
  • Surface-Active Agents / chemistry*
  • Survival Analysis


  • Antibiotics, Antineoplastic
  • Apolipoprotein A-I
  • Blood Proteins
  • Cyanoacrylates
  • Dextrans
  • Surface-Active Agents
  • polyethylbutylcyanoacrylate
  • Poloxamer
  • Doxorubicin