Synthesis and properties of 2',4'-BNA(NC), a second generation BNA

S M Abdur Rahman; Sayori Seki; Kazushige Utsuki; Satoshi Obika; Kazuyuki Miyashita; Takeshi Imanishi

doi:10.1093/nass/49.1.5

Synthesis and properties of 2',4'-BNA(NC), a second generation BNA

Nucleic Acids Symp Ser (Oxf). 2005:(49):5-6. doi: 10.1093/nass/49.1.5.

Authors

S M Abdur Rahman¹, Sayori Seki, Kazushige Utsuki, Satoshi Obika, Kazuyuki Miyashita, Takeshi Imanishi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

PMID: 17150605
DOI: 10.1093/nass/49.1.5

Abstract

We have recently designed and synthesized a novel bridged nucleic acid analogue 2',4'-BNA(NC), bearing an N-O bridged structure, which furnished both higher duplex and triplex-forming abilities and sequence selectivity towards complementary RNA and/or DNA, respectively, and showed excellent resistance against nuclease degradation. Duplex and triplex-forming abilities were slightly higher or similar to those of 2',4'-BNA and nuclease resistance was as high as that of S-oligo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bridged-Ring Compounds / chemical synthesis
Bridged-Ring Compounds / chemistry*
Bridged-Ring Compounds / metabolism
DNA / chemistry
Nucleic Acid Hybridization
Oligonucleotides / chemical synthesis
Oligonucleotides / chemistry*
Oligonucleotides / metabolism
Phosphodiesterase I
RNA / chemistry
Thymidine Monophosphate / analogs & derivatives*
Thymidine Monophosphate / chemical synthesis
Thymidine Monophosphate / chemistry
Thymidine Monophosphate / metabolism

Substances

Bridged-Ring Compounds
Oligonucleotides
Thymidine Monophosphate
RNA
DNA
Phosphodiesterase I
phosphodiesterase I, snake venom