2'-Deoxy-4'-C-ethynyl-2-fluoroadenosine: a nucleoside reverse transcriptase inhibitor with highly potent activity against all HIV-1 strains, favorable toxic profiles and stability in plasma

Nucleic Acids Symp Ser (Oxf). 2006:(50):1-2. doi: 10.1093/nass/nrl001.

Abstract

A working hypothesis to solve the critical problems of existing HAART was proposed. The study based on the hypothesis proved the validity of the hypothesis and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoro-adenosine (4'Ed2FA), a nucleoside reverse transcriptase inhibitor (NRTI) with highly potent activity against all HIV-1 strains, very favourable toxic profiles, and stability in plasma.

MeSH terms

  • Animals
  • Anti-HIV Agents / blood
  • Anti-HIV Agents / pharmacology*
  • Anti-HIV Agents / toxicity
  • Deoxyadenosines / blood
  • Deoxyadenosines / pharmacology*
  • Deoxyadenosines / toxicity
  • Drug Stability
  • HIV-1 / drug effects*
  • Mice
  • Reverse Transcriptase Inhibitors / blood
  • Reverse Transcriptase Inhibitors / pharmacology*
  • Reverse Transcriptase Inhibitors / toxicity

Substances

  • 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine
  • Anti-HIV Agents
  • Deoxyadenosines
  • Reverse Transcriptase Inhibitors