Haplotype probabilities for multiple-strain recombinant inbred lines

Genetics. 2007 Mar;175(3):1267-74. doi: 10.1534/genetics.106.064063. Epub 2006 Dec 6.


Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Crosses, Genetic
  • Haplotypes / genetics*
  • Markov Chains
  • Mice
  • Mice, Inbred Strains / genetics*
  • Models, Genetic*
  • Probability