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Comparative Study
. 2007 Mar;175(3):1267-74.
doi: 10.1534/genetics.106.064063. Epub 2006 Dec 6.

Haplotype Probabilities for Multiple-Strain Recombinant Inbred Lines

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Comparative Study

Haplotype Probabilities for Multiple-Strain Recombinant Inbred Lines

Friedrich Teuscher et al. Genetics. .
Free PMC article


Recombinant inbred lines (RIL) derived from multiple inbred strains can serve as a powerful resource for the genetic dissection of complex traits. The use of such multiple-strain RIL requires a detailed knowledge of the haplotype structure in such lines. Broman (2005) derived the two- and three-point haplotype probabilities for 2(n)-way RIL; the former required hefty computation to infer the symbolic results, and the latter were strictly numerical. We describe a simpler approach for the calculation of these probabilities, which allowed us to derive the symbolic form of the three-point haplotype probabilities. We also extend the two-point results for the case of additional generations of intermating, including the case of 2(n)-way intermated recombinant inbred populations (IRIP).


F<sc>igure</sc> 1.—
Figure 1.—
The production of eight-way RIL by selfing (A) and by sibling mating (B) and of eight-way RIL+ by selfing (C) and by sibling mating (D).

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