Rapamycin: FK506's fraternal twin or distant cousin?

Immunol Today. 1991 May;12(5):137-40. doi: 10.1016/S0167-5699(05)80040-4.

Abstract

Rapamycin (RPM) is the latest in a series of new bacterial-derived immunosuppressants. Here, Randall Morris compares and contrasts the mechanism of action and immune-modulating potential of RPM with the structurally-similar FK506.

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry*
  • Anti-Bacterial Agents / pharmacology
  • Antifungal Agents / chemistry*
  • Antifungal Agents / pharmacology
  • B-Lymphocytes / drug effects
  • Humans
  • Immunosuppressive Agents / chemistry*
  • Immunosuppressive Agents / pharmacology
  • Polyenes / chemistry*
  • Polyenes / pharmacology
  • Sirolimus
  • T-Lymphocytes / drug effects
  • Tacrolimus

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Immunosuppressive Agents
  • Polyenes
  • Sirolimus
  • Tacrolimus