Abstract
Rapamycin (RPM) is the latest in a series of new bacterial-derived immunosuppressants. Here, Randall Morris compares and contrasts the mechanism of action and immune-modulating potential of RPM with the structurally-similar FK506.
MeSH terms
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Animals
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Anti-Bacterial Agents / chemistry*
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Anti-Bacterial Agents / pharmacology
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Antifungal Agents / chemistry*
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Antifungal Agents / pharmacology
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B-Lymphocytes / drug effects
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Humans
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Immunosuppressive Agents / chemistry*
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Immunosuppressive Agents / pharmacology
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Polyenes / chemistry*
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Polyenes / pharmacology
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Sirolimus
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T-Lymphocytes / drug effects
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Tacrolimus
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Immunosuppressive Agents
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Polyenes
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Sirolimus
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Tacrolimus