Nonallergic rhinitis with eosinophilia syndrome and related disorders

Clin Allergy Immunol. 2007:19:87-100.


NARES is a clinical syndrome consisting of symptoms consistent with AR in which an absence of atopy has been demonstrated by allergen skin testing, with nasal cytology analysis showing greater than 20% eosinophils. Anosmia is a prominent feature not shared with AR. The pathophysiology of NARES is poorly understood, but a key component involves a self-perpetuating, chronic eosinophilic nasal inflammation with development of nasal micropolyposis and polyposis. Mast cells likely play an important role as well. NARES is a risk factor for the development of nasal polyposis and aspirin sensitivity, as well as obstructive sleep apnea. Treatment consists mainly of intranasal corticosteroids with or without the addition of second-generation antihistamines and/or LT receptor antagonists as an adjuvant.

Publication types

  • Review

MeSH terms

  • Eosinophilia / diagnosis
  • Eosinophilia / epidemiology
  • Eosinophilia / etiology*
  • Humans
  • Nasal Mucosa / pathology
  • Rhinitis / classification
  • Rhinitis / diagnosis
  • Rhinitis / epidemiology
  • Rhinitis / etiology*
  • Syndrome