Role of selective arterial secretin injection test in treatment of gastrinoma

Hepatogastroenterology. Nov-Dec 2006;53(72):960-3.

Abstract

Background/aims: To study whether use of the selective arterial secretin injection test increased the rate of tumor localization and curative resection in patients with gastrinoma.

Methodology: Nine patients with gastrinoma were divided into 2 groups, before and after introduction of selective arterial secretin injection test; 4 patients before 1987 (Group 1) and 5 patients after 1988 (Group 2). Clinical results were compared retrospectively between groups.

Results: Localization of primary gastrinoma was made with conventional imaging studies in 1 of the 4 patients in Group 1 and 3 of the 5 patients in Group 2. In contrast, use of the selective arterial secretin injection test was able to localize the primary tumor in 4 of the 5 patients in Group 2. Total gastrectomy was carried out in the 4 patients in Group 1, and pancreatoduodenectomy was the most frequently performed procedure (3 patients) in Group 2. Rate of curative resection was 25% and 80% in Groups 1 and 2, respectively.

Conclusions: These results indicate that combining selective arterial secretin injection test with conventional imaging studies contributes to increasing rate of curative resection of gastrinoma.

MeSH terms

  • Adult
  • Diagnostic Imaging
  • Female
  • Gastrinoma / diagnosis*
  • Gastrinoma / surgery*
  • Humans
  • Injections, Intra-Arterial
  • Male
  • Middle Aged
  • Pancreatic Function Tests*
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / surgery*
  • Prognosis
  • Secretin* / administration & dosage
  • Treatment Outcome

Substances

  • Secretin