Ligand-based vascular targeting of disease

ChemMedChem. 2007 Jan;2(1):22-40. doi: 10.1002/cmdc.200600181.


This review illustrates the basic principles of ligand-based vascular targeting and presents some of the most advanced results obtained in this field, not only in terms of biopharmaceuticals, which are currently being investigated in clinical and preclinical studies, but also in terms of enabling technologies that facilitate target and ligand discovery. Whereas most of the vascular targeting research activities have so far concentrated on tumoral angiogenesis, the development of non-oncological applications has recently gained momentum and is likely to become an important area of modern pharmaceutical research.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Angiogenesis Inhibitors / pharmacology
  • Antibodies / pharmacology
  • Chemistry, Pharmaceutical / methods*
  • Chemistry, Pharmaceutical / trends
  • Drug Delivery Systems / methods*
  • Drug Delivery Systems / trends
  • Drug Design*
  • Drug Evaluation, Preclinical
  • Ligands
  • Medical Oncology / methods*
  • Medical Oncology / trends
  • Pharmacology, Clinical
  • Research / trends
  • Research Design*
  • Technology, Pharmaceutical / methods*
  • Technology, Pharmaceutical / trends
  • Vascular Diseases / pathology
  • Vascular Diseases / therapy*


  • Angiogenesis Inhibitors
  • Antibodies
  • Ligands