The role of splenectomy in HIV-infected patients with relapsing visceral leishmaniasis

Parasitology. 2007 May;134(Pt 5):621-4. doi: 10.1017/S0031182006002058. Epub 2006 Dec 11.


The treatment of visceral leishmaniasis (VL) in HIV-infected patients is characterized by having a protracted course and frequent relapses, despite the use of adequate anti-leishmanial drugs and effective anti-retroviral therapy. A small subset of patients with significant splenomegaly develops severe cytopaenias and chronic leishmania infection. The use of elective splenectomy is effective for restoring the haematological parameters and reduces the need for blood transfusions but it does not avoid relapsing visceral leishmaniasis.

MeSH terms

  • AIDS-Related Opportunistic Infections / complications*
  • AIDS-Related Opportunistic Infections / therapy*
  • Adult
  • Female
  • HIV Infections / complications*
  • Humans
  • Leishmaniasis, Visceral / complications*
  • Leishmaniasis, Visceral / therapy*
  • Male
  • Recurrence
  • Retrospective Studies
  • Splenectomy*