Radiation resistance and stem-like cells in brain tumors

Cancer Cell. 2006 Dec;10(6):454-6. doi: 10.1016/j.ccr.2006.11.008.

Abstract

The concepts of stem cells being resistant to therapy, stem-like cells existing in brain tumors, and these tumors initially responding to therapy followed by recurrence are well documented. On this foundation, a recent paper in Nature has demonstrated that CD133-expressing glioma cells in vivo and in culture are relatively resistant to radiation. The mechanism of resistance involves the cell-cycle-regulating proteins CHK1/CHK2. The data raise many questions about the details of radiobiology of stem-like cells in their native environment within tumors in vivo. These answers may lead to better optimization of radiation treatments and schedules for these patients.

MeSH terms

  • AC133 Antigen
  • Antigens, CD / analysis
  • Brain Neoplasms / pathology
  • Brain Neoplasms / radiotherapy*
  • Glycoproteins / analysis
  • Humans
  • Neoplastic Stem Cells / pathology*
  • Peptides / analysis
  • Radiation Tolerance*

Substances

  • AC133 Antigen
  • Antigens, CD
  • Glycoproteins
  • PROM1 protein, human
  • Peptides