Effect of lifestyle intervention on metabolic coronary heart disease risk factors in obese older adults

Am J Clin Nutr. 2006 Dec;84(6):1317-23. doi: 10.1093/ajcn/84.6.1317.


Background: Coronary heart disease (CHD) risk factors increase with age and body mass index (BMI; in kg/m2). However, whether lifestyle intervention ameliorates metabolic CHD risk factors in obese older adults is unknown.

Objective: The objective was to determine whether lifestyle intervention improves metabolic CHD risk factors in obese older adults.

Design: A 6-mo outpatient randomized controlled trial was conducted in obese (BMI >or= 30) older (>or=65 y) adults randomly assigned to diet and exercise therapy (treatment group; n = 17) or no therapy (control group; n = 10). The main outcomes were CHD risk factors.

Results: Body weight decreased by 8.4% (8.2 kg) in the treatment group; weight did not change significantly (0.7 kg) in the control group (P < 0.001 between groups). Changes between the control and treatment groups, respectively, in waist circumference (1 and -10 cm), plasma glucose (4 and -4 mg/dL), serum triacylglycerols (0 and -45 mg/dL), and systolic (-2 and -10 mm Hg) and diastolic (0 and -8 mm Hg) blood pressure were different (P < 0.05 for all). The number of subjects with the metabolic syndrome decreased by 59% in the treatment group but did not change significantly in the control group (P < 0.05). Serum free fatty acids increased by 10 micromol/L in the control group and decreased by 99 micromol/L in the treatment group (P < 0.05). Changes between the control and treatment groups, respectively, in C-reactive protein (0.8 and -2.5 mg/L) and interleukin 6 (1.6 and -2.4 pg/mL) were different (P < 0.05 for both).

Conclusions: Lifestyle intervention decreases multiple metabolic CHD risk factors simultaneously in obese older adults.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Analysis of Variance
  • Area Under Curve
  • Blood Glucose / metabolism
  • Blood Pressure
  • Body Mass Index
  • C-Reactive Protein / analysis
  • Coronary Disease / blood
  • Coronary Disease / epidemiology*
  • Diet, Reducing*
  • Exercise / physiology*
  • Female
  • Health Status
  • Humans
  • Interleukin-6 / blood
  • Life Style*
  • Lipid Metabolism
  • Male
  • Metabolic Syndrome / blood
  • Metabolic Syndrome / epidemiology*
  • Obesity* / blood
  • Obesity* / complications
  • Obesity* / metabolism
  • Obesity* / therapy
  • Risk Factors
  • Treatment Outcome
  • Weight Loss / physiology


  • Blood Glucose
  • Interleukin-6
  • C-Reactive Protein