Proposed standard nomenclature for the alpha- and beta-globin gene families

Genes Genet Syst. 2006 Oct;81(5):367-71. doi: 10.1266/ggs.81.367.

Abstract

The globin family of genes and proteins has been a recurrent object of study for many decades. This interest has generated a vast amount of knowledge. However it has also created an inconsistent and confusing nomenclature, due to the lack of a systematic approach to naming genes and failure to reflect the phylogenetic relationships among genes of the gene family. To alleviate the problems with the existing system, here we propose a standardized nomenclature for the alpha and beta globin family of genes, based on a phylogenetic analysis of vertebrate alpha and beta globins, and following the Guidelines for Human Gene Nomenclature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Globins / genetics*
  • Humans
  • Multigene Family*
  • Terminology as Topic*

Substances

  • Globins