Effect of pneumoperitoneum on renal perfusion and function: a systematic review

Surg Endosc. 2007 Feb;21(2):152-60. doi: 10.1007/s00464-006-0250-x. Epub 2006 Dec 9.


Background: The precise physiologic consequences of insufflating carbon dioxide into the abdominal cavity during laparoscopy are not yet fully understood. This systematic review aimed to investigate whether pneumoperitoneum results in decreased renal blood flow (RBF) or renal function.

Methods: A literature search was conducted electronically using Medline, Embase, and the Cochrane libraries on 1 July 2005. Various combinations of the medical subject headings--renal blood flow, pneumoperitoneum, renal function, and laparoscopy--were searched in all three databases. Reference lists from articles fulfilling the search criteria were used to identify additional articles.

Results: The literature search retrieved 20 articles concerning RBF and 25 articles concerning renal function during pneumoperitoneum. It was found that 17 of the 20 studies identified a decrease in RBF, and 20 of the 25 studies identified a decrease in renal function during pneumoperitoneum.

Conclusion: There appears to be sufficient evidence to conclude that both renal function and RBF are decreased during pneumoperitoneum. The magnitude of the decrease is dependent on factors such as preoperative renal function, level of hydration, level of pneumoperitoneum, patient positioning, and duration of pneumoperitoneum.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Case-Control Studies
  • Creatinine / urine
  • Glomerular Filtration Rate
  • Humans
  • Kidney Function Tests
  • Laparoscopy / adverse effects
  • Laparoscopy / methods
  • Pneumoperitoneum, Artificial / adverse effects*
  • Pneumoperitoneum, Artificial / methods
  • Reference Values
  • Renal Circulation / physiology*
  • Risk Assessment


  • Creatinine