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. 2006 Dec;23(6):665-7.

[ZNF217 Gene Was Detected in Ovarian Serous Cystadenocarcinoma by Fluorescence in Situ Hybridization]

[Article in Chinese]
Affiliations
  • PMID: 17160949

[ZNF217 Gene Was Detected in Ovarian Serous Cystadenocarcinoma by Fluorescence in Situ Hybridization]

[Article in Chinese]
Mei Zhong et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. .

Abstract

Objective: To investigate amplification of zinc finger protein 217 (ZNF217) gene in ovarian serous cystadenocarcinoma and its clinical significance.

Methods: Twenty three specimens of ovarian carcinoma, 10 specimens of ovarian benign tumors and 7 specimens of normal ovaries and two ovarian cancer cell lines, SKOV3 and HO-8910 were examined by fluorescence in situ hybridization (FISH).

Results: The amplification of ZNF217 was gained in 12 case of ovarian cancers, there was only 1 case in ovarian benign tumor and not amplication in normal ovary.

Conclusion: The amplification of ZNF217 is associated with ovarian cancer. Oncogenes ZNF217 maybe play a role in cell differentiation and indicate poorer survival in patients with ovarian cancer.

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